Matrix metalloproteinase-2 C(-1306)T promoter polymorphism and breast cancer risk in the Saudi population.
نویسندگان
چکیده
منابع مشابه
Matrix metalloproteinase-2 C(-1306)T promoter polymorphism and breast cancer risk in the Saudi population.
Matrix metalloproteinase-2 (MMP-2) is an enzyme with proteolytic activity against matrix proteins, particularly basement membrane constituents. A single nucleotide polymorphism (SNP) at -1306, which disrupts a Sp1-type promoter site (CCACC box), displayed a strikingly lower promoter activity with the T allele. In the present study, we investigate whether this MMP-2 SNP is associated with suscep...
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15 صفحه اولMatrix metalloproteinase-2 (-1306 c>t) promoter polymorphism and risk of colorectal cancer in the Saudi population.
BACKGROUND Matrix metalloproteinase-2 (MMP-2) is an enzyme with proteolytic activity against matrix proteins, particularly basement membrane constituents. A single nucleotide polymorphism (SNP) at -1306, which disrupts a Sp1-type promoter site (CCACC box), results in strikingly lower promoter activity with the T allele. In the present study, we investigated whether this MMP-2 genetic polymorphi...
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In the human genome, chromosome 11 contains a cluster of matrix metalloproteinase (MMP) genes. Single nucleotide polymorphisms in the promoter region of MMP genes are important for MMP expression. A common adenine deletion polymorphism (5A) at position -1171 of the MMP-3 gene promoter (5´-AAAAAACCAT-3´ change to 5´-AAAAACCAT-3´) facilitates transcriptional factor binding and MMP-3 promoter acti...
متن کاملthe role of matrix metalloproteinase-3 functional 5a/6a promoter polymorphism in tumor cell progression and metastasis of breast cancer
in the human genome, chromosome 11 contains a cluster of matrix metalloproteinase (mmp) genes. single nucleotide polymorphisms in the promoter region of mmp genes are important for mmp expression. a common adenine deletion polymorphism (5a) at position -1171 of the mmp-3 gene promoter (5´-aaaaaaccat-3´ change to 5´-aaaaaccat-3´) facilitates transcriptional factor binding and mmp-3 promoter acti...
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ژورنال
عنوان ژورنال: Acta Biochimica Polonica
سال: 2013
ISSN: 1734-154X,0001-527X
DOI: 10.18388/abp.2013_2000